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To investigate the survival outcome of GST overexpression in cancer patients, we retrieved the publicly available fragments per kilobase of transcript per million mapped reads (FPKM) values for GST genes and the respective patient survival probability from The Human Protein Atlas [209]

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4.3 Targeted therapeutic strategies in response to ERS It is well known that both the morphology of biomaterials and the UPR pathway can significantly affect the osteogenic differentiation of stem cells and controlling UPR-mediated osteogenic effects by modulating the surface morphology of biomaterials is expected to be an emerging therapeutic strategy (189, 190) ( Figure 2 )